研究業績 ― 伊藤

原著論文

2018

  1. Ito T, Nakanishi Y, Yamaji N, Murakami S, Schaffer SW. Induction of Growth Differentiation Factor 15 in Skeletal Muscle of Old Taurine Transporter Knockout Mouse. Biol Pharm Bull. 2018;41(3):435-439. doi: 10.1248/bpb.b17-00969.
  2. Ito T, Okazaki K, Nakajima D, Shibata D, Murakami S, Schaffer S. Mass spectrometry-based metabolomics to identify taurine-modified metabolites in heart. Amino Acids, 2018;50(1):117-124. doi: 10.1007/s00726-017-2498-y.

2017

  1. Shimada-Takaura K, Takahashi K, Ito T, Schaffer S. Role for Taurine in Development of Oxidative Metabolism After Birth. Adv Exp Med Biol., 975, 1047-1057 (2017)
  2. Ito T, Yamamoto N, Nakajima S, Schaffer SW. Beta-Catenin and SMAD3 Are Associated with Skeletal Muscle Aging in the Taurine Transpoeter Knockout Mouse.Adv Exp Med Biol.,975, 497-502(2017)
  3. Jong CJ, Ito T, Prentice H, Wu JY, Schaffer SW. Role of Mitochondria and Endoplasmic Reticulum in Taurine-Deficiency-Mediated Apoptosis. Nutrients. 9. pii: E795 (2017)
  4. Schaffer S, Jong CJ, Shetewy A, Ramila KC, Ito T. Impaired Energy Production Contributes to Development of Failure in Taurine Deficient Heart.Adv Exp Med Biol.975:435-446 (2017)

~2016

  1. Schaffer SW, Shimada-Takaura K, Jong CJ, Ito T, Takahashi K. Impaired energy metabolism of the taurine-deficient heart. Amino Acids, 48, 549-558 (2016)
  2. Ito T, Yoshikawa N, Ito H, Schaffer S. Impact of taurine depletion on glucose control and insulin secretion in mice. J Pharmacol Sci., 129, 59-64 (2015)
  3. Jong CJ, Ito T, Schaffer S. The ubiquitin-proteasome system and autophagy are defective in the taurine deficient heart. Amino Acids, 47, 2609-2622 (2015)
  4. Han X, Patters AB, Ito T, Azuma J, Schaffer SW, Chesney RW. Knockout of the TauT gene predisposes C57BL/6 mice to streptozotocin-induced diabetic nephropathy. PLoS One, 10, e0117718 (2015)
  5. Ito T, Miyazaki N, Schaffer S, Azuma J. Potential anti-aging role of taurine via proper protein folding: A study from taurine transporter knockout mouse. Adv Exp Med Biol., 803, 481-487 (2015)
  6. Schaffer SW, Ramila KC, Jong CJ, Shetewy A, Shimada K, Ito T, Azuma J, Cioffi E. Does taurine prolong lifespan by improving heart function? Adv Exp Med Biol., 803, 550-570 (2015)
  7. Jong CJ, Ito T, Azuma J, Schaffer S. Taurine depletion decreases GRP78 expression and downregulates Perk-dependent activation of the unfolded protein response. Adv Exp Med Biol. 803, 571-579 (2015)
  8. Han X, Ito T, Azuma J, Schaffer SW, Chesney RW. The quest for an animal model of diabetic nephropathy and the role of taurine deficiency. Adv Exp Med Biol., 803, 217-226 (2015)
  9. Ramila KC, Jong CJ, Pastukh V, Ito T, Azuma J, Schaffer SW. Role of protein phosphorylation in excitation-contraction coupling in taurine deficient hearts. Am J Physiol., 308:H232-239 (2015)
  10. Ito T, Yoshikawa N, Schaffer SW, Azuma J. Tissue taurine depletion alters metabolic response to exercise and reduces running capacity in mice. J Amino Acids., 2014:964680 (2014)
  11. Ito T, Yoshikawa N, Inui T, Miyazaki N, Schaffer SW, Azuma J. Tissue depletion of taurine accelerates skeletal muscle senescence and leads to early death in mice. PLoS One, 9, e107409 (2014)
  12. Ito T, Oishi S, Takai M, Kimura Y, Uozumi Y, Fujio Y, Schaffer SW, Azuma J. Cardiac and skeletal muscle abnormality in taurine transporter-knockout mice. J Biomed Sci., 17 Suppl 1, S20 (2010)
  13. Jong CJ, Ito T, Mozaffari M, Azuma J, Schaffer S. Effect of beta-alanine treatment on mitochondrial taurine level and 5-taurinomethyluridine content. J Biomed Sci., 17 Suppl 1, S25 (2010)
  14. Ito T, Fujio Y, Schaffer SW, Azuma J. Involvement of transcriptional factor TonEBP in the regulation of the taurine transporter in the cardiomyocyte. Adv Exp Med Biol., 643, 523-532 (2009)
  15. Ito T, Muraoka S, Takahashi K, Fujio Y, Schaffer SW, Azuma J. Beneficial effect of taurine treatment against doxorubicin-induced cardiotoxicity in mice. Adv Exp Med Biol., 643, 65-74 (2009)
  16. Ito T, Pastukh V, Solodushko V, Azuma J, Schaffer SW. Effect of taurine on protein kinase C isoforms: role in taurine's actions? Adv Exp Med Biol., 643, 3-11 (2009)
  17. Ito T, Kimura Y, Uozumi Y, Takai M, Muraoka S, Matsuda T, Ueki K, Yoshiyama M, Ikawa M, Okabe M, Schaffer SW, Fujio Y, Azuma J. Taurine depletion caused by knocking out the taurine transporter gene leads to cardiomyopathy with cardiac atrophy. J Mol Cell Cardiol., 44, 927-937 (2008)
  18. Yamamoto Y, Hoshino Y, Ito T, Nariai T, Mohri T, Obana M, Hayata N, Uozumi Y, Maeda M, Fujio Y, Azuma J. Atrogin-1 ubiquitin ligase is upregulated by doxorubicin via p38-MAP kinase in cardiac myocytes. Cardiovasc Res., 79, 89-96 (2008)
  19. Ito T, Fujio Y, Takahashi K, Azuma J. Degradation of NFAT5, a transcriptional regulator of osmotic stress-related genes, is a critical event for doxorubicin-induced cytotoxicity in cardiac myocytes. J Biol Chem., 282, 1152-1160 (2007)
  20. Yamane M, Matsuda T, Ito T, Fujio Y, Takahashi K, Azuma J. Rac1 activity is required for cardiac myocyte alignment in response to mechanical stress. Biochem. Biophys. Res. Commun., 353, 1023-1027 (2007)
  21. Tougou K, Fukuda T, Ito T, Yamazaki H, Fujio Y, Azuma J. Genetic polymorphism of bile acid CoA: amino acid N-acyltransferase in Japanese individuals. Drug Metab Pharmacokinet., 22, 125-128 (2007)
  22. Kimura R, Maeda M, Arita A, Oshima Y, Obana M, Ito T, Yamamoto Y, Mohri T, Kishimoto T, Kawase I, Fujio Y, Azuma J. Identification of cardiac myocytes as the target of interleukin 11, a cardioprotective cytokine. Cytokine, 38, 107-115 (2007)
  23. Ito T, Asakura K, Tougou K, Fukuda T, Kubota R, Nonen S, Fujio Y, Azuma J. Regulation of cytochrome P450 2E1 under hypertonic environment through TonEBP in human hepatocytes. Mol Pharmacol., 72, 173-181 (2007)
  24. Ito T, Fujio Y, Uozumi Y, Matsuda T, Maeda M, Takahashi K, Azuma J. TauT gene expression is regulated by TonEBP and plays a role in cell survival. Adv Exp Med Biol., 583, 91-98 (2006)
  25. Mohri T, Fujio Y, Maeda M, Ito T, Iwakura T, Oshima Y, Uozumi Y, Segawa M, Yamamoto H, Kishimoto T, Azuma J. Leukemia inhibitory factor induces endothelial differentiation in cardiac stem cells. J Biol Chem., 281, 6442-6447 (2006)
  26. Uozumi Y, Ito T, Hoshino Y, Mohri T, Maeda M, Takahashi K, Fujio Y, Azuma J. Myogenic differentiation induces taurine transporter in association with taurine-mediated cytoprotection in skeletal muscles. Biochem J., 394, 699-706 (2006)
  27. Matsuda T, Fujio Y, Nariai T, Ito T, Yamane M, Takatani T, Takahashi K, Azuma J. N-cadherin signals through Rac1 determine the localization of connexin 43 in cardiac myocytes. J Mol Cell Cardiol., 40, 495-502 (2006)
  28. Uozumi Y, Ito T, Takahashi K, Matsuda T, Mohri T, Kimura Y, Fujio Y, Azuma J. Myogenic induction of taurine transporter prevents dexamethasone-induced muscle atrophy. Adv Exp Med Biol., 583, 265-270 (2006)
  29. Takahashi K, Takatani T, Uozumi Y, Ito T, Matsuda T, Fujio Y, Schaffer SW, Azuma J. Molecular mechanisms of cardioprotection by taurine on ischemia-induced apoptosis in cultured cardiomyocytes. Adv Exp Med Biol., 583, 257-263 (2006)
  30. Hua HM, Ito T, Qiu ZG, Azuma J. [Progress in research on function and mechanism of cardiac vascular system of taurine.] Zhongguo Zhong Yao Za Zhi., 30, 653-658. (2005) Chinese
  31. Matsuda T, Takahashi K, Nariai T, Ito T, Takatani T, Fujio Y, Azuma J. N-cadherin-mediated cell adhesion determines the plasticity for cell alignment in response to mechanical stretch in cultured cardiomyocytes. Biochem. Biophys. Res. Commun., 326, 228-232 (2005)
  32. Takatani T, Takahashi K, Uozumi Y, Matsuda T, Ito T, Schaffer SW, Fujio Y, Azuma J. Taurine prevents the ischemia-induced apoptosis in cultured neonatal rat cardiomyocytes through Akt/caspase-9 pathway. Biochem Biophys Res Commun., 316, 484-489 (2004)
  33. Takatani T, Takahashi K, Jin C, Matsuda T, Cheng X, Ito T, Azuma J. Minoxidil attenuates ischemia-induced apoptosis in cultured neonatal rat cardiomyocytes. J Cardiovasc Pharmacol., 43, 789-794 (2004)
  34. Ito T, Fujio Y, Hirata M, Takatani T, Matsuda T, Muraoka S, Takahashi K, Azuma J. Expression of taurine transporter is regulated through the TonE/TonEBP pathway and contributes to cytoprotection in HepG2 cells. Biochem J., 382, 177-182 (2004)
  35. Fujio Y, Matsuda T, Oshima Y, Maeda M, Mohri T, Ito T, Takatani T, Hirata M, Nakaoka Y, Kimura R, Kishimoto T, Azuma J. Signals through gp130 upregulate Wnt5a and contribute to cell adhesion in cardiac myocytes. FEBS Letters., 573, 202-206 (2004)
  36. Takatani T, Takahashi K, Uozumi Y, Shikata E, Yamamoto Y, Ito T, Matsuda T, Schaffer SW, Fujio Y, Azuma J. Taurine inhibits apoptosis by preventing formation of the Apaf-1/caspase-9 apoptosome. Am J Physiol Cell Physiol., 287, C949-C953 (2004)
  37. Takahashi K, Ohyabu Y, Takahashi K, Solodushko V, Takatani T, Itoh T, Schaffer SW, Azuma J. Taurine renders the cell resistant to ischemia-induced injury in cultured neonatal rat cardiomyocytes. J Cardiovasc Pharmacol., 41, 726-733 (2003)
  38. Itoh T, Takahashi K, Yamauchi Y, Takahashi K, Ueyama S, Schaffer SW, Azuma J. Taurine transporter in cultured neonatal cardiomyocytes: a response to cardiac hypertrophy. Adv Exp Med Biol., 526, 33-40 (2003)
  39. Takatani T, Takahashi K, Itoh T, Takahashi K, Hirata M, Yamamoto Y, Ohmoto M, Schaffer SW, Azuma J. Cellular characterization of taurine transporter in cultured cardiac myocytes and nonmyocytes. Adv Exp Med Biol., 526, 25-31 (2003)

総説・解説

  1. Ito T, Schaffer SW, Azuma J. The effect of taurine on chronic heart failure: actions of taurine against catecholamine and angiotensin II. Amino Acids, 46, 111-119 (2014)
  2. Schaffer SW, Shimada K, Jong CJ, Ito T, Azuma J, Takahashi K. Effect of taurine and potential interactions with caffeine on cardiovascular function. Amino Acids, 46, 1147-1157 (2014)
  3. Schaffer SW, Ito T, Azuma J. Clinical significance of taurine. Amino Acids, 46, 1-5 (2014)
  4. Schaffer SW, Jong CJ, Ito T, Azuma J. Effect of taurine on ischemia-reperfusion injury. Amino Acids, 46, 21-30 (2014)
  5. Schaffer SW, Jong CJ, Ito T, Azuma J. Role of taurine in the pathologies of MELAS and MERRF. Amino Acids, 46, 47-56 (2014)
  6. Schaffer SW, Jong CJ, Warner D, Ito T, Azuma J. Taurine deficiency and MELAS are closely related syndromes. Adv Exp Med Biol., 776, 153-165 (2013)
  7. Ito T, Schaffer SW, Azuma J. The potential usefulness of taurine on diabetes mellitus and its complications. Amino Acids, 42, 1529-1539 (2012)
  8. Ito T, Azuma J. Taurine Depletion-Related Cardiomyopathy in Animals. Cardiomyopathies - From Basic Research to Clinical Management, Prof. Josef Veselka (Ed.), ISBN: 978-953-307-834-2 (2012)

総説・解説(日本語)

  1. 川﨑安都紗、小野鮎子、水田尚志、神谷充伸、大脇豊、大脇豊弘、伊藤崇志、村上茂;海藻および海藻加工製品のタウリン含量の分析.タウリンリサーチ,3, 24-26 (2017)
  2. 平修、常山幸一、川崎安都紗、小野鮎子、前川昭、伊藤崇志、宮崎照雄、城本淳、小林春輝、大森肇、片野肇、村上茂;筋肉中のタウリンの可視化.タウリンリサーチ,3, 30-32 (2017)
  3. 伊藤崇志;骨格筋においてタウリン欠乏により引き起こされるシグナル伝達変動の解析.タウリンリサーチ,3, 30-32 (2017)
  4. 加藤俊宏、伊藤崇志、山下剛範、米田操、馬寧;タウリントランスポーターの発現と骨量との関連.タウリンリサーチ,3, 33-35 (2017)
  5. 伊藤崇志;タウリン欠乏と骨格筋老化の関連性.タウリンリサーチ,2, 4-6 (2016)
  6. 伊藤崇志;心筋、骨格筋において組織タウリンと寿命に関連はあるか?タウリンリサーチ,1, 9-11 (2015)
  7. 伊藤 崇志, 東 純一; 心血管病におけるタウリン.循環器内科,75, 637-644 (2014)
  8. 伊藤 崇志, 東純一; タウリンの動脈硬化予防薬としての可能性, 日本薬理学雑誌, 123, 311-317 (2004)

著書

  1. 読んで効く!タウリンのはなし 村上茂監修 国際タウリン研究会日本部会編著 成山堂(2016)
  2. 薬学生のための処方解析トレーニング 門林宗男、前田初男、編著 化学同人 

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