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下畑 隆明しもはたたかあき

プロフィール

所属 海洋生物資源学部
職名 准教授
研究室 食品工学研究室 (内線 1611)
E-mail takshimo (末尾に「@fpu.ac.jp」をつけてください)
ウェブサイト
最終学歴 徳島大学 大学院栄養生命科学教育部 博士後期課程
学位
所属学会 日本細菌学会、日本食品微生物学会、日本生化学会、日本カンピロバクター研究会
職歴 平成23年4月 徳島大学 大学院ヘルスバイオサイエンス研究部 予防環境栄養学分野 助教
平成27年4月 徳島大学 大学院医歯薬学研究部 予防環境栄養学分野 助教

研究活動

専門 食品微生物学、食品衛生学
研究活動の紹介
キーワード

著書・論文

1. Maria Ulfa, Momoyo Azuma, Masami Sato, Takaaki Shimohata*(corresponding author), Shiho Fukushima, Junko Kido, Mariko Nakamoto, Takashi Uebanso, Kazuaki Mawatari, Takahiro Emoto, Mmasatake Akutagawa, Yohsuke Kinouchi, Akira Takahashi. Inactivation ofnactivation of Extended-spectrum β-lactamase (ESBL)-producing Escherichia coli by UVA-LED irradiation system. doi:10.2152/jmi.67.163. J Med Invest. 67(1.2):163-169. 2020.

2. Anh Quoc Nguyen, Takaaki Shimohata*(corresponding author), Sho Hatayama, Aya Tentaku, Junko Kido, Thi Mai Houng Bui, Takashi Uebanso, Kazuaki Mawatari, Akira Takahashi. Type III Secretion Effector VopQ of Vibrio parahaemolyticus Modulates Central Carbon Metabolism in Epithelial Cells. Doi:10.1128/mSphere.00960-19. mSphere. Mar 18;5(2) 2020.

3. Takashi Uebanso T, Ayumi Yoshimoto, Shinta Aizawa, Maya Nakamura, Rumiko Masuda, Takaaki Shimohata, Kazuaki Mawatari, Akira Takahashi. Glycolate is a Novel Marker of Vitamin B2 Deficiency Involved in Gut Microbe Metabolism in Mice. Doi:10.3390/nu12030736. Nutrients. Mar 11;12(3) 2020.

4. Takaaki Shimohata*(corresponding author), Kazuaki Mawatari, Takashi Uebanso, Airi Honjo, Akari Tsunedomi, Sho Hatayama, Yuri Sato, Junko Kido, Risa Nishisaka, Ayumi Yoshimoto, Tomoko Yamashita, Sachie Amano, Miki Maetani-Yasui, Hitomi Iba, Yumi Harada, Mutsumi Nakahashi, Sonoko Yasui-Yamada, Yasuhiro Hamada, Tadahiko Nakagawa, Masahiro Sogabe, Takahiro Emoto, Masatake Akutagawa, Toshiya Okahisa, Yohsuke Kinouchi, Akira Takahashi. Bacterial Contamination of Hemodialysis Devices in Hospital Dialysis Wards. Doi:10.2152/jmi.66.148. J Med Invest. 66(1.2):148-152. 2019.

5. Risa Nishisaka-Nonaka, Kazuaki Mawatari, Tomomi Yamamoto, Mizuki Kojima, Takaaki Shimohata, Takasha Uebanso, Mutsumi Nakahashi, Takahiro Emoto, Masatake Akutagawa, Yohsuke Kinouchi, Takahiro Wada, Masayuki Okamoto, Hiroshi Ito, Ken-Ichi Yoshida, Tomo Daidoji, Takaaki Nakaya, Akira Takahashi. Irradiation by ultraviolet light-emitting diodes inactivates influenza a viruses by inhibiting replication and transcription of viral RNA in host cells. Doi:10.1016/j.jphotobiol.2018.10.017. J Photochem Photobiol B. Dec;189:193-200. 2018.

6. Aya Tentaku, Takaaki Shimohata*(corresponding author), Sho Hatayama, Junko Kido, Anh Quoc Nguyen, Yuna Kanda, Shiho Fukushima, Takashi Uebanso, Taketoshi Iwata, Kazuaki Mawatari, Nagakatsu Harada, Akira Takahashi. Host cellular unfolded protein response signaling regulates Campylobacter jejuni invasion. Doi:10.1371/journal.pone.0205865. PLoS One. Oct 15;13(10):e0205865. 2018.

7. Akari Tsunedomi, Katsuyuki Miyawaki, Akinori Masamura, Mutsumi Nakahashi, Kazuaki Mawatari, Takaaki Shimohata, Takashi Uebanso, Yohsuke Kinouchi, Masatake Akutagawa, Takahiro Emoto, Akira Takahashi. UVA-LED device to disinfect hydroponic nutrient solution. Doi:10.2152/jmi.65.171. J Med Invest. 65(3.4):171-176. 2018.

8. Shohei Sasaki, Hiroko Segawa, Ai Hanazaki, Ruri Kirino, Toru Fujii, Kayo Ikuta, Miwa Noguchi, Sumire Sasaki, Megumi Koike, Kazuya Tanifuji, Yuji Shiozaki, Ichiro Kaneko, Sawako Tatsumi, Takaaki Shimohata, Yoshichika Kawai, Sonoko Narisawa, Jose Luis Millán, Ken-Ichi Miyamoto. A Role of Intestinal Alkaline Phosphatase 3 (Akp3) in Inorganic Phosphate Homeostasis. Doi:10.1159/000493379. Kidney Blood Press Res. Sep 13;43(5):1409-1424. 2018.

9. Ayumi Yoshimoto, Takashi Uebanso, Mutsumi Nakahashi, Takaaki Shimohata, Kazuaki Mawatari , Akira Takahashi. Effect of prenatal administration of low dose antibiotics on gut microbiota and body fat composition of newborn mice. Doi:10.3164/jcbn.17-53. J Clin Biochem Nutr. Mar;62(2):155-160. 2018.

10. Sho Hatayama, Takaaki Shimohata*(corresponding author), Sachie Amano, Junko Kido, Anh Quoc Nguyen, Yuri Sato, Yuna Kanda, Aya Tentaku, Shiho Fukushima, Mutsumi Nakahashi, Takashi Uebanso, Kazuaki Mawatari, Akira Takahashi. Cellular Tight Junctions Prevent Effective Campylobacter jejuni Invasion and Inflammatory Barrier Disruption Promoting Bacterial Invasion from Lateral Membrane in Polarized Intestinal Epithelial Cells. Doi:10.3389/fcimb.2018.00015. Front Cell Infect Microbiol. Jan 30;8:15. 2018.

11. Junko Kido, Takaaki Shimohata*(corresponding author), Sachie Amano, Sho Hatayama, Anh Quoc Nguyen, Yuri Sato, Yuna Kanda, Aya Tentaku, Shiho Fukushima, Mutsumi Nakahashi, Takashi Uebanso, Kazuaki Mawatari, Akira Takahashi. CFTR reduces microtubule-dependent Campylobacter jejuni invasion. Doi:10.1128/IAI.00311-17. Infect Immun. Sep 20;85(10). 2017.

12. Takashi Uebanso, Saki Kano, Ayumi Yoshimoto, Chisato Naito, Takaaki Shimohata, Kazuaki Mawatari, Akira Takahashi. Effects of Consuming Xylitol on Gut Microbiota and Lipid Metabolism in Mice. Doi:10.3390/nu9070756. Nutrients. Jul 14;9(7). 2017.

13. Takashi Uebanso, Ai Ohnishi, Reiko Kitayama, Ayumi Yoshimoto, Mutsumi Nakahashi, Takaaki Shimohata, Kazuaki Mawatari, Akira Takahashi. Effects of Low-Dose Non-Caloric Sweetener Consumption on Gut Microbiota in Mice. Doi:10.3390/nu9060560. Nutrients. Jun 1;9(6). 2017.

14. Yanfei Hou, Mutsumi Nakahashi, Kazuaki Mawatari, Takaaki Shimohata, Takashi Uebanso, Yumi Harada, Akari Tsunedomi, Takahiro Emoto, Masatake Akutagawa, Yohsuke Kinouchi, Akira Takahashi. Combined treatment of UVA irradiation and antibiotics induces greater bactericidal effects on Vibrio parahaemolyticus. Doi:10.2152/jmi.63.63. J Med Invest. 63:63-67. 2016.

15. Ngoc Quang Phan, Takashi Uebanso, Takaaki Shimohata, Mutsumi Nakahashi, Kazuaki Mawatari, Akira Takahashi. DNA-Binding Protein HU Coordinates Pathogenicity in Vibrio parahaemolyticus. Doi:10.1128/JB.00306-15. J Bacteriol. 197:2958-2964. 2015.

16. Zehong Su, Gaojian Lian, Kazuaki Mawatari, Ping Tang, Shuya He, Takaaki Shimohata, Yimou Wu, Weidong Yin, Akira Takahashi. Identification and Purification of the CPD Photolyase in Vibrio parahaemolyticus RIMD2210633. Doi:10.1111/php.12481. Photochem Photobiol. 91:1165-1172. 2015.

17. Mutsumi Aihara, Xin Lian, Takaaki Shimohata, Takashi Uebanso, Kazuaki Mawatari, Yumi Harada, Masatake Akutagawa, Yohsuke Kinouchi, Akira Takahashi. Vegetable surface sterilization system using UVA light-emitting diodes. Doi:10.2152/jmi.61.285. J Med Invest. 61:285-290. 2014.

18. Sachie Negoro, Takaaki Shimohata*(corresponding author), Sho Hatayama, Yuri Sato, Mari Matsumoto, Hitomi Iba, Mutsumi Aihara, Takashi Uebanso, Yasuhiro Hamada, Yoshikazu Nishikawa, Shinji Yamasaki, Kazuaki Mawatari, Akira Takahashi. Campylobacter jejuni infection suppressed Cl⁻ secretion induced by CFTR activation in T-84 cells. Doi:10.1016/j.jiac.2014.07.007. J Infect Chemother. 20:682-688. 2014.

19. Mutsumi Nakahashi, Kazuaki Mawatari, Akiko Hirata, Miki Maetani, Takaaki Shimohata, Takashi Uebanso, Yasuhiro Hamada, Masatake Akutagawa, Yohsuke Kinouchi, Akira Takahashi. Simultaneous irradiation with different wavelengths of ultraviolet light has synergistic bactericidal effect on Vibrio parahaemolyticus. Doi:10.1111/php.12309. Photochem Photobiol. 90:1397-1403. 2014.

20. Kazuaki Mawatari, Emiko Yoshioka, Satomi Toda, Sonoko Yasui, Hiroko Furukawa, Takaaki Shimohata, Takamasa Ohnishi, Masaki Morishima, Nagakatsu Harada, Akira Takahashi, Hiroshi Sakaue, Yutaka Nakaya. Enhancement of endothelial function inhibits left atrial thrombi development in an animal model of spontaneous left atrial thrombosis. Doi:10.1253/circj.cj-13-1398. Circ J. 78:1980-1988. 2014.

21. Takafumi Yakabe, Takaaki Shimohata, Akira Takahashi. Lactobacillus brevis KB290 enhances IL-8 secretion by Vibrio parahaemolyticus-infected Caco-2 cells. Doi:10.4014/jmb.1207.07020. J Microbiol Biotechnol. Jan;23(1):118-124. 2013.

22. Takaaki Shimohata*(corresponding author), Kazuaki Mawatari, Hitomi Iba, Masakazu Hamano, Sachie Negoro, Shoko Asada, Mutsumi Aihara, Akiko Hirata, Zehong Su, Akira Takahashi. VopB1 and VopD1 are essential for translocation of type III secretion system 1 effectors of Vibrio parahaemolyticus. Doi:10.1139/w2012-081. Can J Microbiol. Aug;58(8):1002-1007. 2012.

23. Tam Thi Thanh Le, Kazuaki Mawatari, Miki Maetani, Tomomi Yamamoto, Sayaka Hayashida, Hitomi Iba, Mutsumi Aihara, Akiko Hirata, Takaaki Shimohata, Takashi Uebanso, Akira Takahashi. VP2118 has major roles in Vibrio parahaemolyticus response to oxidative stress. Doi:10.1016/j.bbagen.2012.06.019. Biochim Biophys Acta. Oct;1820(10):1686-1692. 2012.

24. Le Thi Tuyet Nhung, Hirofumi Nagata, Akira Takahashi, Mutsumi Aihara, Toshihiro Okamoto, Takaaki Shimohata, Kazuaki Mawatari, Masatake Akutagawa, Yohsuke Kinouchi, Masanobu Haraguchi. Sterilization effect of UV light on Bacillus spores using TiO(2) films depends on wavelength. Doi:10.2152/jmi.59.53. J Med Invest. 59(1-2):53-58. 2012.

25. Sonoko Yasui, Kazuaki Mawatari, Ran Morizumi, Hiroko Furukawa, Takaaki Shimohata, Harada N, Takahashi A, Nakaya Y. Hydrogen peroxide inhibits insulin-induced ATP-sensitive potassium channel activation independent of insulin signaling pathway in cultured vascular smooth muscle cells. Doi:10.21152/jmi.59.36. J Med Invest. 59(1-2):36-44. 2012.

26. Masayuki Nakano, Eiki Yamasaki, Akitoyo Ichinose, Takaaki Shimohata, Akira Takahashi, Junko K Akada, Kazuyuki Nakamura, Joel Moss, Toshiya Hirayama, Hisao Kurazono. Salmonella enterotoxin (Stn) regulates membrane composition and integrity. Doi:10.1242/dmm.009324. Dis Model Mech. Jul;5(4):515-521. 2012.

27. Nhung Thi Tuyet Le, Hirofumi Nagata, Mutsumi Aihara, Akira Takahashi, Toshihiro Okamoto, Takaaki Shimohata, Kazuaki Mawatari, Yohsuke Kinouchi, Masatake Akutagawa, Masanobu Haraguchi. Additional effects of silver nanoparticles on bactericidal efficiency depend on calcination temperature and dip-coating speed. Doi:10.1128/AEM.00049-11. Appl Environ Microbiol. Aug 15;77(16):5629-5634. 2011.

28. Hiroko Furukawa, Kazuaki Mawatari, Kei Koyama, Sonoko Yasui, Ran Morizumi, Takaaki Shimohata, Nagakatsu Harada, Akira Takahashi, Yutaka Nakaya. Telmisartan increases localization of glucose transporter 4 to the plasma membrane and increases glucose uptake via peroxisome proliferator-activated receptor γ in 3T3-L1 adipocytes. Doi:10.1016/j.ejphar.2011.04.008. Eur J Pharmacol. Jun 25;660(2-3):485-91. 2011.

29. Takaaki Shimohata, Masayuki Nakano, Xin Lian, Tomomi Shigeyama, Hitomi Iba, Akiko Hamamoto, Masaki Yoshida, Nagakatsu Harada, Hironori Yamamoto, Masayuki Yamato, Kazuaki Mawatari, Toshiaki Tamaki, Yutaka Nakaya, Akira Takahashi. Vibrio parahaemolyticus infection induces modulation of IL-8 secretion through dual pathway via VP1680 in Caco-2 cells. Doi:10.1093/infdis/jiq070. J Infect Dis. Feb 15;203(4):537-544. 2011.

30. Yutaka Nakaya, Takaaki Shimohata, Sayaka Haraguchi, Toshiyuki Nakao, Jun Minaguchi, Haruo Sumitani, Nagakatsu Harada, Hiroshi Sakaue. Severe catabolic state after an overnight fast in patients with chronic renal failure. Doi:10.1016/j.nut.2010.04.008. Nutrition. Mar;27(3):329-332. 2011.

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