先端セミナー(2017/3/8)

生物資源学先端セミナー
(後援:科研費新学術領域生合成リデザイン)

演 題:Hapalindole alkaloid biosynthesis:
     a treasure trove of novel enzymatic transformations

演 者:Department of Chemistry, University of Pittsburgh, USA
     Prof. Xinyu Liu

Hapalindole-type alkaloids are a large family of cytotoxic indole monoterpenoids produced by stigonematalean cyanobacteria Fischerella sp. and Hapalosiphon sp. With nearly 100 members isolated and characterized to date in this class of natural products, the genetic and molecular basis for their biogenesis was virtually unknown before 2013. My laboratory recently made a series of breakthroughs in deciphering their biosynthetic logics that provided fundamental insights on how Nature generates structural diversities within hapalindole-type alkaloids and how these strategies are distinct from those used for other microbial/plant alkaloids and/or terpenoids. This talk will summarize our work in this area, with particular focus on the origin and evolution of structural diversity within this family of natural products.

日 時: 平成29年3月8日(火) 15:00~16:30 

場 所: 生物資源学部棟1階会議室

連絡先:担当教員名  濱野  吉十 (内3408)

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