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Maruyama Chitose
- Profile
- Research Interest
- Selected Publications
- Social Activities
- Educational Activies
- Additional Information
Profile
| Affiliation | Faculty of Biotechnology / Department of Bioscience and Biotechnology |
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| Title | Associate Professor |
| Room | Faculty of Biotechnology BW406 (Extension3406) |
| ( at = @ ) | |
| Website | https://applied-microbiology-fpu.com |
| Education | Ph.D. |
| Degree | |
| Academic Societies | Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA), The Society for Biotechnology, Japan (SJB), The Society for Actinomycetes Japan (SAJ) |
| Career | <2004 - 2007> Research assistant, Fukui prefectural University <2007 - 2008> Assistant teacher, Fukui University <2008 - 2012> Research assistant (NEDO), Fukui prefectural University <2013 - 2017> Postdoctoral Fellow, Technology research association for Next-Generation Natural Products Chemistory <2017 - 2019> Assistant professor, Fukui prefectural University <2019 - date> Associate professor, Fukui prefectural University |
Research Interest
| Research Field | Applied microbiology, Natural product chemistry, Chemical biology |
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| Research Summary | Our research is focused on the biosynthesis and bioengineering of microbial peptide natural products and in the discovery of new enzyme biocatalysts. Our studies are performed at the chemistry-biology interface and involve a number of sophisticated approaches that include heterologous biosynthesis, mutasynthesis, chemoenzymatic total synthesis, genome mining, and in vitro and in vivo biochemical analysis. |
| Keywords | Biosynthesis, secondary metabolites, peptide, non-ribosomal peptide synthetase, NRPS |
Selected Publications
researchmap https://researchmap.jp/FPU_Maruyama
Google Scholar https://scholar.google.co.jp/citations?user=r4ZTE5kAAAAJ&hl=ja&oi=ao
1. C. Maruyama, Y. Hamano, tRNA-dependent amide bond–forming enzymes in peptide natural product biosynthesis, Current Opinion in Chemical Biology, 59, 164-171 (2020)
2. C. Maruyama, Y. Chinone, S. Sato, F. Kudo, K. Ohsawa, J. Kubota, J. Hashimoto, I. Kozone, T. Doi, K. Shin-ya, T. Eguchi, Y. Hamano*, C-Methylation of S-adenosyl-L-methionine occurs prior to cyclopropanation in the biosynthesis of 1-amino-2-methylcyclopropanecarboxylic acid (norcoronamic acid) in a bacterium, biomolecules, 10(5), 775, (2020).
3. S. Hayashi, Y. Ogasawara, Y. Satoh, C. Maruyama, Y. Hamano, and T. Dairi*, Off-loading mechanism of products in polyunsaturated fattyacid synthases, ACS Chem. Biol., 15, 651-656, (2020).
4. Y. Ogasawara*, Y. Nakagawa, C. Maruyama, Y. Hamano, and T. Dairi*, In vitro characterization of MitE and MitB: Formation of N-acetylglucosaminyl-3-amino-5-hydroxybenzoyl-MmcB as a key intermediate in the biosynthesis of antitumor antibiotic mitomycins, Bioorg. Med. Chem. Lett., 29(16), 2076-2078, (2019).
5. S. Hayashi, M. Naka, K. Ikeuchi, M. Ohtsuka, K. Kobayashi, Y. Satoh, Y. Ogasawara, C. Maruyama, Y. Hamano, and T. Ujihara, T. Dairi*, Control mechanism for carbon chain length in polyunsaturated fatty acid synthases, Angew Chem Int Ed Engl., 58(20), 6605-6610 (2019).
6. S. Hayashi, Y. Satoh, Y. Ogasawara, C. Maruyama, Y. Hamano, T. Ujihara and T. Dairi*, Control mechanism for cis double bond formation by polyunsaturated fatty acid synthases, Angew Chem Int Ed Engl., 58(8), 2326-2330 (2019).
Community Engagement
Educational Activites
| Classes | Graduation thesis, Laboratory Course in Microbiology, Elementary Laboratory Course in Applied Biology, Seminar in Bioscience of Molecular Functions, Seminar in Bioscience |
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| Office Hour | 17:00 - 19:00 |
| Available Topics |