• Profile
• Research Interest
• Selected Publications
• Social Activities
• Educational Activies
• Additional Information

Profile

Research Interest

Selected Publications

【Original Articles (Peer-reviewed; English only; Main articles only)】
1)Kobayashi S, Sata F, Sasaki S, et al. Genetic association of aromatic hydrocarbon receptor (AHR) and cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) polymorphisms with dioxin blood concentrations among pregnant Japanese women. Toxicol Lett. 2013; 219: 269-278.
2)Kobayashi S, Sata F, Sasaki S, et al. Combined effects of AHR, CYP1A1, and XRCC1 genotypes and prenatal maternal smoking on infant birth size: Biomarker assessment in the Hokkaido Study. Reprod Toxicol. 2016; 65: 295-306.
3)Kobayashi S, Sata F, Miyashita C, et al. Dioxin-metabolizing genes in relation to effects of prenatal dioxin levels and reduced birth size: the Hokkaido Study. Reprod Toxicol. 2017; 67: 111-116.
4)Kobayashi S, Sata F, Miyashita C, et al. Gender-specific association of exposure to non-dioxin-like polychlorinated biphenyls during pregnancy with methylation levels of H19 and long interspersed nuclear element-1 in cord blood in the Hokkaido study. Toxicology. 2017; 390: 135-145.
5)Kobayashi S, Sata F, Sasaki S, et al. Modification of adverse health effects of maternal active and passive smoking by genetic susceptibility: Dose-dependent association of plasma cotinine with infant birth size among Japanese women-The Hokkaido Study. Reprod Toxicol. 2017; 74: 94-103.
6)Kobayashi S, Sata F, Hanaoka T, et al. Association between maternal passive smoking and increased risk of delivering small-for-gestational-age infants at full-term using plasma cotinine levels from the Hokkaido Study: a prospective birth cohort. BMJ Open. 2019; 9: e023200.
7)Kobayashi S, Kishi R, Saijo Y, et al. Association of blood mercury levels during pregnancy with infant birth size by blood selenium levels in the Japan Environment and Children’s Study: A prospective birth cohort. Environ Int. 2019; 125: 418-429.
8)Kobayashi S, Sata F, Murata K, et al. Dose-dependent associations between prenatal caffeine consumption and small-for-gestational-age, preterm birth and reduced birthweight in the Japan Environment and Children’s Study. Paediatr Perinat Epidemiol. 2019; 33: 185-194.
9)Kobayashi S, Sata F, Goudarzi H, et al. Associations among perfluorooctanesulfonic/perfluorooctanoic acid levels, nuclear receptor gene polymorphisms, and lipid levels in pregnant women in the Hokkaido study. Sci Rep. 2021; 11: 9994.
10)Kobayashi S, Sata F, Ikeda-Araki A, et al. Associations among maternal perfluoroalkyl substance levels, fetal sex-hormone enzymatic gene polymorphisms, and fetal sex hormone levels in the Hokkaido study. Reprod Toxicol. 2021; 105: 221-231.
11)Kobayashi S, Sata F, Miyashita C, et al. Associations between maternal mono-(2-ethylhexyl) phthalate levels, nuclear receptor gene polymorphisms, and fatty acid levels in pregnant Japanese women in the Hokkaido study. Reprod Toxicol. 2022; 107: 22-32.
12)Kobayashi S, Sata F, Ikeda-Araki A, et al. Relationships between maternal perfluoroalkyl substance levels, polymorphisms of receptor genes, and adverse birth outcomes in the Hokkaido birth cohort study, Japan. Reprod Toxicol. 2022; 107: 112-122.
13)Kobayashi S, Itoh S, Miyashita C, et al. Impact of prenatal exposure to mercury and selenium on neurodevelopmental delay in children in the Japan Environment and Children’s Study using the ASQ-3 questionnaire: a prospective birth cohort. Environ Int. 2022; 168: 107448.
14)Saito Y, Kobayashi S*, Ikeda-Araki A, et al. Association between pre-pregnancy body mass index and gestational weight gain and perinatal outcomes in pregnant women diagnosed with gestational diabetes mellitus: The Japan Environment and Children's Study. J Diabetes Investig. 2022; 13 (5): 889-899. (*Corresponding author)
15)Saito Y, Kobayashi S*, Ito S, et al. Neurodevelopmental delay up to the age of 4 years in infants born to women with gestational diabetes mellitus: The Japan Environment and Children's Study. J Diabetes Investig. 2022; 13 (12): 2054-2062. (*Corresponding author)
16)Cho K, Kobayashi S*, Araki A, et al. Prenatal alcohol exposure and adverse fetal growth restriction: findings from the Japan Environment and Children's Study. Pediatr Res. 2022; 92 (1): 291-298. (*Corresponding author)
17)Nakamura Y, Kobayashi S*, Cho K, et al. Prenatal metal concentrations and physical abnormalities in the Japan Environment and Children's Study. Pediatr Res. 2024; 95 (7): 1875-1882 (*Corresponding author)
18)Kobayashi S, Saijo Y, Itoh M, et al. Effects of the maternal work environment on psychological distress during pregnancy: A cross-sectional research―The Japan Environment and Children’s Study. J Occup Environ Med. 2025; 67 (2): 89-99.
19)Kobayashi S, Saijo Y, Iwata H, et al. Association between the occupation of pregnant women’s partners and risks of infant low birth weight and preterm birth in a prospective birth cohort: the Japan Environment and Children’s Study. J Occup Environ Med. 2025; 67 (3): 161-170.
20)Kobayashi S, Iwata H, Yamaguchi T, et al. Mediation of prenatal cotinine and 8-hydroxy-2’-deoxyguanosine levels on infant birth size in the Japan Environment and Children’s Study (JECS). Reprod Toxicol. 2025; 135: 108905.
21)Kobayashi S, Iwata H, Yamaguchi T, et al. Effects of maternal occupation on low birth weight and preterm birth: A prospective birth cohort study in the first trimester―The Japan Environment and Children’s Study. Int J Gynaecol Obstet. 2026; 172 (2): 991-1008.

【Reviews (Peer-reviewed; English only; Main articles only)】
1)Kobayashi S, Sata F, Kishi R. Gene-environment interactions related to maternal exposure to environmental and lifestyle-related chemicals during pregnancy and the resulting adverse fetal growth: A review. Environ Health Prev Med. 2022; 27: 24.
2)Kobayashi S, Sata F, Saijo Y, et al. Prenatal chemical exposures and fetal growth: a narrative review of gene-environment interactions (2025). Pediatr Res. 2026. DOI: https://doi.org/10.1038/s41390-026-04869-w

For other research achievements, please refer to Researchmap.

【Researchmap Homepage Address】 https://researchmap.jp/hucehssk?lang=en

Community Engagement

【Committee members, lecturers, etc.】
Nov,2016-Mar,2025
Public Health Monitoring Report Member (Environmental Health)(Japanese Society of Public Health)
Nov,2017-Mar,2023
Councilor (Hokkaido Society of Public Health)
May,2019-Mar,2023
Committee Member (Data Management Review Project, Japan Environment and Children's Study (JECS), Ministry of Environment (MOE), Japan)
Sep,2020-Jun,2021
Delegate (Japan Epidemiological Association)
Mar,2021-Mar,2022
Manager (Young Researchers' Association, Japanese Society for Hygiene)
Apr,2022-Mar,2023
Committee Member (Sapporo District Management Council, JECS, MOE, Japan)
Jul,2022-Mar,2024
Committee Member (Epidemiology Expert Committee, Hokkaido Regional Center, JECS, MOE, Japan)
Apr,2023-Mar,2024
Committee Member (Data Management Review Working Group, JECS, MOE, Japan)
Apr,2023-Present
Committee Member (Literature Search Working Group, Expert Committee on the Examination of Concentration Standards for Chemical Management in Workplace, National Institute of Occupational Safety and Health/Ministry of Health, Labour and Welfare, Japan)
Apr,2026-Present
Building Review Board Member (Fukui City, Japan)
Apr,2026-Present
Manager (Developmental Origins and Health and Disease (DOHaD) Epidemiological Seminar, DOHaD-Japan)
Apr,2026-Present
Editorial Board Member (Japanese Society for Hygiene)

Educational Activites

Additional Information

【Awards】
Aug,2015　Travel Award (27th Conference of the International Society for Environmental Epidemiology (ISEE2015))
Nov,2017　Oral Presentation Award (76th Annual Meeting of Japanese Society of Public Health)
Nov,2019　Hokkaido Public Health Association Award (Hokkaido Public Health Association)
Mar,2021　Encouragement Award (Japanese Society for Hygiene)
Mar,2023　The Best Reviewer Award (Environ Health Prev Med., 2022; Japanese Society for Hygiene)
Mar,2024　The Best Reviewer Award (Environ Health Prev Med., 2023; Japanese Society for Hygiene)
Mar,2025　The Best Reviewer Award (Environ Health Prev Med., 2024; Japanese Society for Hygiene)
Mar,2026　The Best Reviewer Award (Environ Health Prev Med., 2025; Japanese Society for Hygiene)