- Research Interest
- Selected Publications
- Social Activities
- Educational Activies
- Additional Information
|Affiliation||Faculty of Biotechnology / Department of Bioscience and Biotechnology|
|Room||Faculty of Biotechnology BW406 (Extension3406)|
|( at = @ )|
|Academic Societies||Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA),
The Society for Biotechnology, Japan (SJB),
The Society for Actinomycetes Japan (SAJ)
|Career||<2004 - 2007>
Research assistant, Fukui prefectural University
<2007 - 2008>
Assistant teacher, Fukui University
<2008 - 2012>
Research assistant (NEDO), Fukui prefectural University
<2013 - 2017>
Postdoctoral Fellow, Technology research association for Next-Generation Natural Products Chemistory
<2017 - 2019>
Assistant professor, Fukui prefectural University
<2019 - date>
Associate professor, Fukui prefectural University
|Research Field||Applied microbiology, Natural product chemistry, Chemical biology|
|Research Summary||Our research is focused on the biosynthesis and bioengineering of microbial peptide natural products and in the discovery of new enzyme biocatalysts. Our studies are performed at the chemistry-biology interface and involve a number of sophisticated approaches that include heterologous biosynthesis, mutasynthesis, chemoenzymatic total synthesis, genome mining, and in vitro and in vivo biochemical analysis.|
|Keywords||Biosynthesis, secondary metabolites, peptide, non-ribosomal peptide synthetase, NRPS|
Google Scholar https://scholar.google.co.jp/citations?user=r4ZTE5kAAAAJ&hl=ja&oi=ao
1. C. Maruyama, Y. Hamano, tRNA-dependent amide bond–forming enzymes in peptide natural product biosynthesis, Current Opinion in Chemical Biology, 59, 164-171 (2020)
2. C. Maruyama, Y. Chinone, S. Sato, F. Kudo, K. Ohsawa, J. Kubota, J. Hashimoto, I. Kozone, T. Doi, K. Shin-ya, T. Eguchi, Y. Hamano*, C-Methylation of S-adenosyl-L-methionine occurs prior to cyclopropanation in the biosynthesis of 1-amino-2-methylcyclopropanecarboxylic acid (norcoronamic acid) in a bacterium, biomolecules, 10(5), 775, (2020).
3. S. Hayashi, Y. Ogasawara, Y. Satoh, C. Maruyama, Y. Hamano, and T. Dairi*, Off-loading mechanism of products in polyunsaturated fattyacid synthases, ACS Chem. Biol., 15, 651-656, (2020).
4. Y. Ogasawara*, Y. Nakagawa, C. Maruyama, Y. Hamano, and T. Dairi*, In vitro characterization of MitE and MitB: Formation of N-acetylglucosaminyl-3-amino-5-hydroxybenzoyl-MmcB as a key intermediate in the biosynthesis of antitumor antibiotic mitomycins, Bioorg. Med. Chem. Lett., 29(16), 2076-2078, (2019).
5. S. Hayashi, M. Naka, K. Ikeuchi, M. Ohtsuka, K. Kobayashi, Y. Satoh, Y. Ogasawara, C. Maruyama, Y. Hamano, and T. Ujihara, T. Dairi*, Control mechanism for carbon chain length in polyunsaturated fatty acid synthases, Angew Chem Int Ed Engl., 58(20), 6605-6610 (2019).
6. S. Hayashi, Y. Satoh, Y. Ogasawara, C. Maruyama, Y. Hamano, T. Ujihara and T. Dairi*, Control mechanism for cis double bond formation by polyunsaturated fatty acid synthases, Angew Chem Int Ed Engl., 58(8), 2326-2330 (2019).
|Classes||Graduation thesis, Laboratory Course in Microbiology, Elementary Laboratory Course in Applied Biology, Seminar in Bioscience of Molecular Functions, Seminar in Bioscience|
|Office Hour||17:00 - 19:00|