Fumihito Hasebe


Affiliation Faculty of Biotechnology / Department of Bioscience and Biotechnology
Title Assistant Professor
Room Faculty of Biotechnology BW404 (Extension3404)
E-mail ufhasebe(at) ( at = @ )
Education Ph.D., The University of Tokyo
Academic Societies Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA)
The Society for Actinomycetes Japan (SAJ)
Career 2014 - 2016 Postdoctoral Fellow, The University of Tokyo, Japan
2016 - 2021 Assistant Professor, University of Shizuoka, Japan
2021 - date Assistant Professor, Fukui Prefectural University, Japan

Research Interest

Research Field Applied microbiology, Natural product chemistry, Chemical biology
Research Summary Microbes have various metabolic enzymes/proteins, because of their diversity. Our research group focuses on the biosynthesis and bioengineering of microbial metabolites and the discovery of novel metabolites and enzymes/proteins. Our studies are performed at the chemistry-biology interface and involve several sophisticated approaches that include heterologous biosynthesis, mutasynthesis, chemoenzymatic total synthesis, genome mining, and in vitro and in vivo biochemical analysis.
Keywords Biosynthesis, primary metabolites, amino acid, secondary metabolites

Selected Publications

1)Fumihito Hasebe, Kazuya Adachi, Kazuya Yamanaka, Tadao Oikawa, Chitose Maruyama, Yoshimitsu Hamano.: Constitutive and high gene expression in the diaminopimelate pathway accelerates ε-poly-L-lysine production in Streptomyces albulus. The Journal of Antibiotics Volume 76, Issue 9, 522-531 (2023)
2) Fumihito Hasebe.: MetW regulates the enzymatic activity of MetX in Pseudomonas. Bioscience, Biotechnology, and Biochemistry Volume 85, Issue 2, 351-358 (2021)
3) Fumihito Hasebe, Kenichi Matsuda, Taro Shiraishi, Yushi Futamura, Takeshi Nakano, Takeo Tomita, Ken Ishigami, Hikari Taka, Reiko Mineki, Tsutomu Fujimura, Hiroyuki Osada, Tomohisa Kuzuyama & Makoto Nishiyama.: Amino-group carrier-protein-mediated secondary metabolite biosynthesis in Streptomyces. Nature Chemical Biology Volume 12, 967-972 (2016)
4) Yuko Kanemaru, Fumihito Hasebe, Takeo Tomita, Tomohisa Kuzuyama, Makoto Nishiyama.: Two ATP-Binding Cassette Transporters Involved in (S)-2-Aminoethyl-Cysteine Uptake in Thermus thermophilus. Journal of Bacteriology Volume 195, 3845–3853 (2013)

Community Engagement

Educational Activites

Classes Graduation thesis, Laboratory Course in Microbiology, Elementary Laboratory Course in Applied Biology, Seminar in Bioscience of Molecular Functions, Seminar in Bioscience
Office Hour 17:00 - 19:00
Available Topics

Additional Information

research map: