- Research Interest
- Selected Publications
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- Additional Information
|Affiliation||Faculty of Biotechnology / Department of Bioscience|
|Room||Faculty of Biotechnology BW408 (Extension3408)|
|hamano ( at = @ )|
|Academic Societies||Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA)
The Society for Biotechnology, Japan (SJB)
The Society for Aactinomycetes Japan (SAJ)
|Career||1998 - 1999 Sanofi K.K., Japan
2002 - 2003 Postdoctoral Fellow, University of Arizona, USA
2003 - 2008 Assistant Prof., Fukui Prefectural University, Japan
2008 - 2011 Lecturer, Fukui Prefectural University, Japan
2011 - date Associate Prof., Fukui Prefectural University, Japan
|Research Field||Applied microbiology, Natural product chemistry, Chemical biology|
|Research Summary||Research in the Hamano group is focused on the biosynthesis and bioengineering of microbial peptide natural products and in the discovery of new enzyme biocatalysts. Our studies are performed at the chemistry-biology interface and involve a number of sophisticated approaches that include heterologous biosynthesis, mutasynthesis, chemoenzymatic total synthesis, genome mining, and in vitro and in vivo biochemical analysis.|
|Keywords||Biosynthesis, secondary metabolites, peptide, non-ribosomal peptide synthetase, NRPS|
1. Motoyoshi Noike, Takashi Matsui, Koichi Ooya, Ikuo Sasaki, Shouta Ohtaki, Yoshimitsu Hamano, Chitose Maruyama, Jun Ishikawa, Yasuharu Satoh, Hajime Ito, Hiroyuki Morita†, and Tohru Dairi, A peptide ligase and the ribosome cooperate to synthesize the peptide pheganomycin, Nature Chem. Biol., 11, 71-76 (2015).
2. Yoshimitsu Hamano, Naoko Kito, Akihiro Kita, Yuuki Imokawa, Kazuya Yamanaka, Chitose Maruyama, and Hajime Katano, ε-Poly-L-lysine peptide chain length regulated by the linkers connecting the transmembrane domains of ε-poly-L-lysine synthetase, Appl. Environ. Microbiol., 80, 4993-5000 (2014).
3. Kohei Uematsu†, Yuto Minami, Chitose Maruyama, Yoshimitsu Hamano, and Hajime Katano, Voltammetric study of the transfer of ε-poly-L-lysine at nitrobenzene | water interfase, J. Electroanal. Chem. 719, 138-142 (2014).
|Classes||Bioactive Molecules, Special Lecture in Biotechnology, Graduation thesis, Laboratory Course in Microbiology, Elementary Laboratory Course in Applied Biology, Seminar in Bioscience of Molecular Functions, Seminar in Bioscience|
Our program provides an exciting training opportunity for students and postdocs who wish to explore the chemistry, biochemistry and genetics of microbial natural products. Through our on-going research projects, the Hamano lab offers a broad training envi