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Ito Takashi

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Date of Birth 1978.3.17
Affiliation Faculty of Biotechnology / Department of Bioscience
Title Associate professor
Room Faculty of Biotechnology 420 (Extension3420)
E-mail tito ( at = @ )
Website http://www.fpu.ac.jp/labs/food/index.html
Education Osaka University
Academic Societies
Career 2005 Researcher, Osaka University
2007 Research fellow, South Alabama University
2009 Assistant professor, Hyogo University of Health Sciences
2017 Associate professor, Fukui Prefecture University

Research Interest

Research Field Pharmacology, Food function
Research Summary Research in the role of taurine, which is abundantly contained in fishes and shells, on the aging, especially skeletal muscle aging.
Keywords taurine, aging, sarcopenia

Selected Publications

1.Takashi Ito et al. Induction of growth differentiation factor 15 in skeletal muscle of old taurine transporter knockout mouse.Biol Pharm Bull., (Accepted)
2.Takashi Ito et al.Mass spectrometry-based metabolomics to identify taurine-modified metabolites in heart.Amino Acids, (Accepted)
3.Takashi Ito et al.Beta-Catenin and SMAD3 Are Associated with Skeletal Muscle Aging in the Taurine Transpoeter Knockout Mouse. Adv Exp Med Biol.,975, 497-502(2017)
4.Takashi Ito et al. Impaired energy metabolism of the taurine-deficient heart. Amino Acids, 48, 549-558 (2016)
5.Takashi Ito et al. Taurine depletion causes lean phenotype and enhancement of glucose disposal. J Pharmacol Sci., 129, 59-64 (2015)
6.Chian Ju Jeong et al. The ubiquitin-proteasome system and autophagy are defective in the taurine deficient heart. Amino Acids, 47, 2609-2622 (2015)
7.Xiaobin Han et al. Knockout of the TauT gene predisposes C57BL/6 mice to streptozotocin-induced diabetic nephropathy. PLoS One, 10, e0117718 (2015)
8.Takashi Ito et al. Potential anti-aging role of taurine via proper protein folding: A study from taurine transporter knockout mouse. Adv Exp Med Biol., 803, 481-487 (2015)
9.KC Ramila et al. Role of protein phosphorylation in excitation-contraction coupling in taurine deficient hearts. Am J Physiol., 308:H232-239 (2015)
10.Takashi Ito et al. Tissue taurine depletion alters metabolic response to exercise and reduces running capacity in mice. J Amino Acids., 2014:964680 (2014)
11.Takashi Ito et al. Tissue depletion of taurine accelerates skeletal muscle senescence and leads to early death in mice. PLoS One, 9, e107409 (2014)
12.Takashi Ito et al. Taurine depletion caused by knocking out the taurine transporter gene leads to cardiomyopathy with cardiac atrophy. J Mol Cell Cardiol., 44, 927-937 (2008)
13.Takashi Ito et al. Degradation of NFAT5, a transcriptional regulator of osmotic stress-related genes, is a critical event for doxorubicin-induced cytotoxicity in cardiac myocytes. J Biol Chem., 282, 1152-1160 (2007)
14.Takashi Ito et al. Regulation of cytochrome P450 2E1 under hypertonic environment through TonEBP in human hepatocytes. Mol Pharmacol., 72, 173-181 (2007)
15.Yoriko Uozumi et al. Myogenic differentiation induces taurine transporter in association with taurine-mediated cytoprotection in skeletal muscles. Biochem J., 394, 699-706 (2006)
16.Takashi Ito et al. Expression of taurine transporter is regulated through the TonE/TonEBP pathway and contributes to cytoprotection in HepG2 cells. Biochem J., 382, 177-182 (2004)

Social Activities

Educational Activies

Classes Food hygienics, Elementary Laboratory Course in Biology, Elementary Laboratory Course in Biological Chemistry
Office Hour
Available Topics Pharmacology of Taurine
Research in food function

Additional Information