Affiliation Department of Advanced Aquaculture Science, Faculty of Marine Science and Technology
Title Associate Professor
Room (Extension)
E-mail ( at = @ )
Education Graduate School of Veterinary Medicine, Nihon University
Degree Ph. D. of veterinary medicine
Academic Societies International Society of Fish & Shellfish Immunology
International Society of Developmental & Comparative Immunology
Career 2016.1-2018.3 Research Specialist C at University of Pennsylvania, School of Veterinary Medicine, Department of Pathobiology
2011.1–2015.12 Postdoctoral Researcher at University of Pennsylvania, School of Veterinary Medicine, Department of Pathobiology
supported by a JSPS Postdoctoral Fellowships for Research Abroad (2011 Apr- 2013 Mar)
2008.6 – 2010.12 Postdoctoral fellow at Laboratory of Fish Immunology, Friedrich-Loeffler-Institute, supported by the Alexander-von-Humboldt foundation
2008.4 – 2008.6 Postdoctoral fellow at Nihon University (Laboratory of Fish Pathology)

Research Interest

Research Field Fish Immunology
Research Summary

Selected Publications

Original Articles
1) Xu Z*, Takizawa F*, Casadei E, Shibasaki Y, Ding Y, J.C. Sauters T, Yu Y, Salinas I, Sunyer JO, Specialization of mucosal immunoglobulins in pathogen control and microbiota homeostasis occurred early in vertebrate evolution. Science Immunology. 5, eaay3254 (2020). (*Equal contribution)

2) Sepahi A, Tacchi L, Casadei E, Takizawa F, LaPatra SE, Salinas I. CK12a, a CCL19-like chemokine that orchestrates both nasal and systemic antiviral immune responses in rainbow trout. The Journal of Immunology, 199(11):3900-3913, 2017.

3) Han Z, Sagum CA, Takizawa F, Ruthel G, Berry CT, Kong J, Sunyer JO, Freedman BD, Bedford MT, Sidhu SS, Sudol M, Harty RN. Ubiquitin Ligase WWP1 Interacts with Ebola Virus VP40 To Regulate Egress. Journal of virology, 27;91(20), 2017.

4) Kelly C, Takizawa F, Sunyer JO, Salinas I. Rainbow trout (Oncorhynchus mykiss) secretory component binds to commensal bacteria and pathogens. Scientific reports, 7:41753, 2017.

5) Takizawa F, Magadan S, Parra D, Xu, Z, Korytář T, Boudinot P, Sunyer JO. Novel teleost CD4-bearing cell populations provide insights into the evolutionary origins and primordial roles of CD4+ lymphocytes and CD4+ macrophages. The Journal of Immunology, 196(11):4522-35, 2016.

6) Xu Z, Takizawa F, Parra D, Gomez D, Jørgensen L, LaPatra S, Sunyer JO. Mucosal immunoglobulins at respiratory surfaces mark an ancient association that predates the emergence of tetrapods. Nature communications, 12;7:10728, 2016.

7) Takizawa F, Araki K, Ohtani M, Toda H, Saito Y, Lampe VS, Dijkstra JM, Ototake M, Moritomo T, Nakanishi T, Fischer U. Transcription analysis of two Eomesodermin genes in lymphocyte subsets of two teleost species. Fish & Shellfish Immunology, 36(1):215-22, 2014.

8) Takizawa F, Dijkstra JM, Kotterba P, Korytář T, Kock H, Köllner B, Jaureguiberry B, Nakanishi T, and Fischer U. The expression of CD8α discriminates distinct T cell subsets in teleost fish. Developmental & Comparative Immunology, 35(7): 752-63, 2011.

9) Takizawa F, Koppang EO, Ohtani M., Nakanishi T, Hashimoto K, Fischer U, and Dijkstra JM. Constitutive high expression of interleukin-4/13A and GATA-3 in gill and skin of salmonid fishes suggests that these tissues form Th2-skewed immune environments. Molecular immunology, 48(12-13): 1360-8, 2011.

10) Toda H, Saito Y, Koike T, Takizawa F, Araki K, Yabu T, Somamoto T, Suetake H, Suzuki Y, Ototake M, Moritomo T, Nakanishi T. Conservation of characteristics and functions of CD4 positive lymphocytes in a teleost fish. Developmental & Comparative Immunology, 35(6):650-60, 2011.

11) Toda H, Shibasaki Y, Koike T, Ohtani M, Takizawa F, Ototake M, Moritomo T, Nakanishi T. Alloantigen-specific killing is mediated by CD8-positive T cells in fish. Developmental & Comparative Immunology, 33(4):646-52, 2009.

12) Kobayashi I, Saito K, Moritomo T, Araki K, Takizawa F, Nakanishi T. Characterization and localization of side population (SP) cells in zebrafish kidney hematopoietic tissue. Blood, 111(3):1131-7, 2008.

13) Takizawa F, Mizunaga Y, Araki K, Moritomo T, Ototake M, Nakanishi T. GATA3 mRNA in ginbuna crucian carp (Carassius auratus langsdorfii): cDNA cloning, splice variants and expression analysis. Developmental & Comparative Immunology, 32(8): 898-907, 2008.

14) Takizawa F, Araki K., Kobayashi I, Moritomo T, Ototake M, Nakanishi T. Molecular cloning and expression analysis of T-bet in ginbuna crucian carp (Carassius auratus langsdorfii). Molecular immunology, 45(1):127-36, 2008.

15) Takizawa F, Araki K, Ito K., Moritomo T, Nakanishi T. Expression analysis of two Eomesodermin homologues in zebrafish lymphoid tissues and cells. Molecular immunology, 44(9):2324-31, 2007.

Review Articles
1) Yamaguchi T*, Takizawa F*, Furihata M, Soto-Lampe V, Dijkstra JM, Fischer U. Teleost cytotoxic T cells. Fish & Shellfish Immunology. 2019 Dec;95:422-439. (*Equal contribution)

2) Yamaguchi T*, Takizawa F*, Fischer U, Dijkstra JM. Along the axis between type 1 and type 2 immunity; principles conserved in evolution from fish to mammals. Biology (Basel). 17;4(4):814-59, 2015. (*Equal contribution)

3) Parra D*, Takizawa F*, Sunyer JO. Evolution of B Cell Immunity. Annual review of animal biosciences. 1:65-97, 2013. (*Equal contribution)

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